Research on Biological Properties of Ruthenium (III) Heterocyclic Schiff Base Complexes
K. Sampath1, S. Sathiyaraj2, P. Indhumathi3, M. Shanmugaprakash4

1K. Sampath, Department of Chemistry, Kumaraguru College of Technology, Coimbatore (Tamil Nadu), India.

2S. Sathiyaraj, Department of Chemistry, Dr. N.G.P. Arts and Science College, Coimbatore (Tamil Nadu), India.

3P. Indhumathi, Department of Chemistry, Shri Nehru Maha Vidyalaya College of Arts & Science, Coimbatore (Tamil Nadu), India.

4M. Shanmugaprakash, Department of Biotechnology, Kumaraguru College of Technology, Coimbatore (Tamil Nadu), India.

Manuscript received on 06 October 2019 | Revised Manuscript received on 20 October 2019 | Manuscript Published on 26 December 2019 | PP: 332-334 | Volume-8 Issue-12S October 2019 | Retrieval Number: L108610812S19/2019©BEIESP | DOI: 10.35940/ijitee.L1086.10812S19

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Abstract: A set of ruthenium complexes of +3 oxidation state were synthesized with the available ruthenium precursors and the synthesized Schiff base ligands. The complexes are formed by the substitution of the ligand in the octahedral metal precursors. Samples are characterized using analytical as well as spectroscopic techniques. To ascertain pharmacological properties binding study with DNA were carried out. Further, cleavage studies were performed with gel electrophoresis. The in vitro antitumor property was analysed in HeLa tumor cell lines.

Keywords: Ruthenium, Complexes, +3 Oxidation State, Antitumor.
Scope of the Article: Bio-Science and Bio-Technology