396e3d57186c1f28fcb-7403 20230317055002095 beie:beie director@blueeyesintelligence.org WEB-FORM International Journal of Innovative Technology and Exploring Engineering IJITEE 22783075 10.35940/ijitee https://www.ijitee.org/ 04 30 2023 12 5 Department of Pharmaceutics, Research Scholar, Bhagwant University, Ajmer (Rajasthan), India Deepesh Lall https://orcid.org/0000-0001-9928-5226 Dr. Neeraj Sharma Department of Pharmaceutics, Professor/ Principal, Bhagwant University, Ajmer (Rajasthan), India Dr. Shruti Rathore, Rathore https://orcid.org/0000-0001-6311-6543 Department of Pharmaceutics, Professor/ Principal, LCIT School of Pharmacy, Bilaspur (Chhattisgarh), India Various non-invasive administration has been recently coming as an excellent alternative to conventional administrative mechanism. A transdermal drug delivery system with polymeric microneedles presents the most attractive method among all these because of its low rejection rate, higher bioavailability, super convenience, ease of administration and ease of termination, biodegradable and persistence in the skin care industry. However, the skin physiochemical properties made them to protect the inner environment and this mechanism play as excellent barrier for TDDS, hence polymeric bio dissolvable and biocompatible microneedle can be excellent choice. In this research, we fabricated and characterized the different proportions of polymer blend solution for effective and improved bioavailability and delivery of Ondansetron HCl. We characterized TDDS on progression of mechanically strength determination by folding endurance, flatness study, gelatin sheets beds penetration application, percentage drug content releasement under FT-IR and studied microscopic images the shape and size of microneedle. In addition, desired physical properties and an excellent alternative method had been established with high efficiency inherent to TDDS which expected to find a broad range of application fields. 04 30 2023 12 17 CC BY-NC-ND 4.0 10.35940/BEIESP.CrossMarkPolicy www.ijitee.org true No, I did not receive. No conflicts of interest to the best of our knowledge. No, the article does not require ethical approval and consent to participate with evidence. Not relevant. All authors have equal participation in this article. 10.35940/ijitee.E9493.0412523 https://www.ijitee.org/portfolio-item/E94930412523/