The Effects of Prostaglandin Analogs on Intraocular Pressure in Human Eye for Open Angle Glaucoma
Shabab Akbar1, Sapna Ratan Shah2
1Shabab Akbar, Bio Mathematical lab, Centre of Computational Biology and Bioinformatics, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
2Sapna Ratan Shah*, Bio Mathematical lab, Centre of Computational Biology and Bioinformatics, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
Manuscript received on November 14, 2020. | Revised Manuscript received on December 04, 2020. | Manuscript published on December 10, 2021. | PP: 176-180 | Volume-10 Issue-2, December 2020 | Retrieval Number: 100.1/ijitee.A81951110120| DOI: 10.35940/ijitee.A8195.1210220
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The effects of Prostaglandin Analogs on intraocular pressure and increased aqueous outflow via trabecular meshwork into the schlemm’s canal has been studied in this present research paper. Aqueous humor is an outflow, which flows at the back of the iris in the posterior chamber all the way through the pupil aperture, out into the anterior chamber, and drain from the eye via drainage slope. The eye keeps on making aqueous humor in the ciliary body and it passes through the trabecular meshwork into the scheme of the canal, the key drainage from the eye and it finally goes to the “collector channels” and due to the less amount of aqueous humor fluid flow from the drainage angle, the pressure in the eye starts to increase. For this study, the canal of Schlemm is assumed as a permeable channel. And it is connected by trabecular meshwork. The inner layer of the canal’s wall has been assumed as permeable. And the aqueous humor drains into the canal through this porous tissue wall. The objective of this paper is to discuss the effect of prostaglandin analogs on intraocular pressure as the Prostaglandin Analogs work by increasing the outflow of aqueous from the eye.
Keywords: Collector channel, Open angle Glaucoma, Prostaglandin, Latanoprost, Bimatoprost, Latanoprostene.