Trinuclear Schiff Base Complexes Containing P-Phenylene Diamine, 2, 3-Pentanedione and 3-Aminocoumarin Ligand: Synthesis, Characterization, DNA Cleavage and Antimicrobial Activity
Kuttiyapillai Sivakumar1, Venkatachalam Chandrasekaran2
1Kuttiyapillai Sivakumar Assistant Professor, Department of Chemistry, V.S.B Engineering College, Karur, Tamil Nadu, India.
2Dr. Venkatachalam Chandrasekaran Assistant Professor, Department of Chemistry, Government Arts College (A) , Salem Tamil Nadu, India.
Manuscript received on February 10, 2020. | Revised Manuscript received on February 23, 2020. | Manuscript published on March 10, 2020. | PP: 2283-2299 | Volume-9 Issue-5, March 2020. | Retrieval Number: E2498039520/2020©BEIESP | DOI: 10.35940/ijitee.E2498.039520
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Abstract: Trinuclear Schiff base complexes were synthesized by using p-phenylene diamine, 2,3-pentanedione and 3-aminocoumarin and Cu (II), Ni (II), Mn (II), Zn(II) and Cr(III) chloride salts. The category of compound was [M3LCl6 ]. All trinuclear compounds were analyzed by C, H&N analysis and spectral studies. Mechanism of thermal analysis of trinuclear Schiff base metal complexes was studied. The electrophoresis data confirmed that Schiff base compounds cleaved DNA with Hydrogen peroxide. Additionally, the antibacterial action was tested by disc diffusion method. The efficiency of compounds was assessed against selected microbes. The result of minimum inhibitory concentration confirmed that trinuclear Schiff base metal compounds have got more efficiency.
Keywords: p-phenylene diamine, 2,3-pentanedione and 3-Aminocoumarin C, H & N Analysis, DNA Cleavage study and thermal analysis
Scope of the Article: Structural Reliability Analysis