Design, Fabrication and Characterization of Antiemetic Transdermal Patches Loaded Dissolvable Microneedles
Deepesh Lall1, Neeraj Sharma2, Shruti Rathore3
1Deepesh Lall, Department of Pharmaceutics, Research Scholar, Bhagwant University, Ajmer (Rajasthan), India.
2Dr. Neeraj Sharma, Department of Pharmaceutics, Professor/ Principal, Bhagwant University, Ajmer (Rajasthan), India.
3Dr. Shruti Rathore, Department of Pharmaceutics, Professor/ Principal, LCIT School of Pharmacy, Bilaspur (Chhattisgarh), India.
Manuscript received on 09 March 2023 | Revised Manuscript received on 15 March 2023 | Manuscript Accepted on 15 April 2023 | Manuscript published on 30 April 2023 | PP: 12-17 | Volume-12 Issue-5, April 2023 | Retrieval Number: 100.1/ijitee.E94930412523 | DOI: 10.35940/ijitee.E9493.0412523
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Various non-invasive administration methods have recently emerged as an excellent alternative to conventional administrative mechanisms. A transdermal drug delivery system with polymeric microneedles presents the most attractive method among all these because of its low rejection rate, higher bioavailability, convenience, ease of administration, and ease of termination, as well as its biodegradable and persistent nature in the skin care industry. However, the skin’s physicochemical properties enable it to protect the inner environment, and this mechanism acts as an excellent barrier for TDDS. Hence, polymeric bio-dissolvable and biocompatible microneedles can be an excellent choice. In this research, we fabricated and characterised different proportions of polymer blend solutions for the effective and improved bioavailability and delivery of Ondansetron HCl. We characterised TDDS by determining mechanical strength progression through folding endurance, flatness study, gelatin sheet bed penetration application, and percentage drug release under FT-IR. We studied microscopic images to examine the shape and size of the microneedle. In addition, desired physical properties and an excellent alternative method have been established, with high efficiency inherent to TDDS, which is expected to find applications in a broad range of fields.
Keywords: Bioavailability, FT-IR, Polymeric Microneedles, Ondansetron HCl.
Scope of the Article: Design and Diagnosis