Design, Fabrication and Characterization of Antiemetic Transdermal Patches Loaded Dissolvable Microneedles
Deepesh Lall1, Neeraj Sharma2, Shruti Rathore3

1Deepesh Lall, Department of Pharmaceutics, Research Scholar, Bhagwant University, Ajmer (Rajasthan), India.
2Dr. Neeraj Sharma, Department of Pharmaceutics, Professor/ Principal, Bhagwant University, Ajmer (Rajasthan), India.
3Dr. Shruti Rathore, Department of Pharmaceutics, Professor/ Principal, LCIT School of Pharmacy, Bilaspur (Chhattisgarh), India.
Manuscript received on 09 March 2023 | Revised Manuscript received on 15 March 2023 | Manuscript Accepted on 15 April 2023 | Manuscript published on 30 April 2023 | PP: 12-17 | Volume-12 Issue-5, April 2023 | Retrieval Number: 100.1/ijitee.E94930412523 | DOI: 10.35940/ijitee.E9493.0412523

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Abstract: Various non-invasive administration has been recently coming as an excellent alternative to conventional administrative mechanism. A transdermal drug delivery system with polymeric microneedles presents the most attractive method among all these because of its low rejection rate, higher bioavailability, super convenience, ease of administration and ease of termination, biodegradable and persistence in the skin care industry. However, the skin physiochemical properties made them to protect the inner environment and this mechanism play as excellent barrier for TDDS, hence polymeric bio dissolvable and biocompatible microneedle can be excellent choice. In this research, we fabricated and characterized the different proportions of polymer blend solution for effective and improved bioavailability and delivery of Ondansetron HCl. We characterized TDDS on progression of mechanically strength determination by folding endurance, flatness study, gelatin sheets beds penetration application, percentage drug content releasement under FT-IR and studied microscopic images the shape and size of microneedle. In addition, desired physical properties and an excellent alternative method had been established with high efficiency inherent to TDDS which expected to find a broad range of application fields. 
Keywords: Bioavailability, FT-IR, Polymeric Microneedles, Ondansetron HCl.
Scope of the Article: Design and Diagnosis