Control of Anesthesia Concentration Using PID Controller
Usharani Shola1, Neelanarayanan V2

1Usharani Shola, Vellore Institute of Technology, Chennai Campus, Tamil Nadu, India.

2Neelanarayanan V, Vellore Institute of Technology, Chennai Campus, Tamil Nadu, India.

Manuscript received on 04 April 2019 | Revised Manuscript received on 11 April 2019 | Manuscript Published on 26 April 2019 | PP: 356-360 | Volume-8 Issue-6S April 2019 | Retrieval Number: F61290486S19/19©BEIESP

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Abstract: Management of anesthesia is significant for both surgery and intensive care. The intravenous anesthetics are widely used to provide steady maintenance and speed recovery compared with inhaled anesthetics. The current work analyses the technique to describe the effects of anesthetic drug Propofol in the introduction of hypnosis on a patient during surgery procedure. The model is developed by considering the regular three-compartmental pharmacokinetics  pharmacodynamics Wiener model and conventional controller for adjustment of Depth of hypnosis through Bispectral Index scale (BIS) value. It provides a reliable and safe methodology for infusing anesthesia using closed loop control technology and analysis of human electroencephalogram (EEG) to measure the depth of anesthesia in patients. Two patient sets of datasets are considered during this procedure. The outcomes obtained for different patients show that the standard model fits the data with the developed Simulink based model. The paper designs the plasma concentration 3-compartmental model using PID controller to control the depth of hypnosis and infusion rate during surgery through the reference value BIS of patient. Because of simplicity and robustness of PID controller, it is widely used for industrial plants. The developed model is compared with sliding mode controller. The results shows the transient control system characteristics of delay time, rise time, peak time, maximum overshoot and settling time.

Keywords: Bispectral Index Scale(BIS), Pharmacokinetics pharmacodynamics (PK-PD), Depth of Hypnosis (DOH), PID Controller, Total Intravenous Anesthesia, Sliding Mode Control(SMC),Target Controlled Infusion(TCI).
Scope of the Article: Innovative Sensing Cloud and Systems