Design of Drug Molecule Based Structure for Smad 3 Protein and Its Insilico Research of Leukemia Utilizing Bioinformatics Software
A. Manikandan1, T. Jayalakshmi2, P. B. Ramesh Babu3
1A. Manikandan, Assistant Professor, School of Bio-Engineering, Department of Genetic Engineering, Bharath University, Chennai, Tamil Nadu, India.
2T. Jayalakshmi, Associate Professor, School of Bio-Engineering, Department of Genetic Engineering, Bharath University, Chennai, Tamil Nadu, India.
3Dr. P. B. Ramesh Babu, Professor, School of Bio-Engineering, Department of Genetic Engineering, Bharath University, Chennai, Tamil Nadu, India.
Manuscript received on 09 August 2019 | Revised Manuscript received on 16 August 2019 | Manuscript Published on 31 August 2019 | PP: 301-306 | Volume-8 Issue-9S2 August 2019 | Retrieval Number: I10620789S219/19©BEIESP DOI: 10.35940/ijitee.I1062.0789S219
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The Research work on rational drug molecules design for Smad3,the conclusion is that out of all the inhibitors chosen for the docking , PTHrP emerged to be the best inhibitor for the protein Smad3.The precise reason for it was its docking energy which was the lowest (docked energy =-29.73), among all other inhibitors used. Hence the conclusion is that Smad3 is the best inhibitor, for Smad3. Hence the task was completed successfully. There are many reasons and factors responsible for induction of cancer. Leukemia is a type of cancer in blood or bone marrow and is characterized by an irregular proliferation of white blood cells.
Keywords: Bioinformatics, Rational Drug, PTHrP Emerged, docking Energy.
Scope of the Article: Bioinformatics