One-Pot Synthesis of N-Benzyl Substituted 2- Aminothiophene-3-Carboxilic Acid Scaffold and their Antibacterial Activity
Venugopalarao Vikram1, Karteek Rao Amperayani2, Umadevi Parimi3
1Venugpalarao Vikram, Department of Chemistry, GITAM University, Rushikonda, Visakhapatnam, India.
2Karteek Rao Amperayani: Department of Chemistry, Gayatri Vidya Parishad college for Degree and PG Courses (A), Rushikonda, Visakhapatnam, India .
3Umadevi Parimi: Department of Chemistry, Gayatri Vidya Parishad College for Degree and PG Courses (A), Rushikonda, Visakhapatnam, India.
Manuscript received on September 14, 2019. | Revised Manuscript received on 24 September, 2019. | Manuscript published on October 10, 2019. | PP: 2546-2549 | Volume-8 Issue-12, October 2019. | Retrieval Number: K15670981119/2019©BEIESP | DOI: 10.35940/ijitee.K1567.1081219
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: 2-aminothiophene is an important pharmacophore in medicinal chemistry which exhibits a wide spectrum of biological activities. An efficient one pot synthesis has been established for the synthesis of novel series of N-benzyl substituted 2-aminothiophene-3-carboxylic acid derivatives. The synthesized compounds were characterized by nuclear magnetic resonance (1H and 13C NMR) and Mass spectrometry. The antimicrobial activity of these compounds were tested on Gramnegative bacteria and Gram-positive bacteria. Among all the synthesized compound 2b, 2c, 2f were found to have good antibacterial activity. Conjugation of the compound and carboxylic acid group has enhanced the activity of all the compounds.
Keywords: 2-Amino-3-Carbomethoxythiophene, N-Benzyl Substituted 2-Aminothiophene-3-Carboxylic Acid, Microbiological Activity.
Scope of the Article: Bio-Science and Bio-Technology