The Role of Bidara Leaf Extract (Ziziphus Mauritiana) on the Prevention of Renal Hypertension in Wistar Strain Rats
Dian Yuliartha Lestari1, Cintantya Pramastri Yuwono2, Dani Pratama Febrianto3

1Dian Yuliartha Lestari, Department of Pathology, Medical Faculty, University of Muhammadiyah Malang, Malang, Indonesia. 

2Cyntantya Pramastri Yuwono, Medical Faculty, University of Muhammadiyah Malang, Malang, Indonesia. 

3Dani Pratama Febrianto, Medical Faculty, University of Muhammadiyah Malang, Malang, Indonesia. 

Manuscript received on 11 January 2020 | Revised Manuscript received on 07 February 2020 | Manuscript Published on 20 February 2020 | PP: 298-300 | Volume-9 Issue-3S January 2020 | Retrieval Number: C10680193S20/2020©BEIESP | DOI: 10.35940/ijitee.C1068.0193S20

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Abstract: Hypertension is ranked the fourth highest disease in the word. Glomerulosclerosis is the initial lesion from kidney failure in patient with hypertension. Bidara leaves have active flavonoid such as saponins and tannins are thought to prevent an increase in blood pressure and repair glomerulosclerosis. This study to prove the effect of bidara leaf extract to decrease hypertension and to prevent glomerulosclerosis. This study was true experimental with Pre and Post Test Control Group Design. This study used male white rats wistar strain. Sample divided into 5 groups (positive group, treatment group with 3 leveled dose, and medicine-control group) and were being observed in 28 days. Hypertension was measured using tail cuff blood pressure. Glomerulus observed randomly with light microscope in 5 different field of view with 400x magnification and scoring by Sclerosis Index (SI). In the linear regression test had R 2 = 0,332 for systolic blood pressure and R 2 = 0,609 for diastolic blood pressure. For glomerulosclerosis we found that the highest SI (369,69) was positive control group, while the lowest SI (84,09) was the group with a dose 400mg/kg/day. Bidara leaves extract have a significant effect on reduce hypertension and glomerulosclerosis.

Keywords: Hypertension, Glomerulosclerosis, Bidara Leaves.
Scope of the Article: Bio-Science and Bio-Technology